Using recombinant Rho protein antagonist in acute spinal cord injury; does this go further from conventional decompressions?
نویسندگان
چکیده
منابع مشابه
Using recombinant Rho protein antagonist in acute spinal cord injury; does this go further from conventional decompressions?
New evidence has suggested the Rho signaling pathway as a target for treatment in acute spinal cord injury (SCI). The Rho signaling pathway plays an important role in neuronal growth inhibition after a CNS injury. Block of Rho pathway is a new potential method to improve recovery after an SCI. Other studies by our group had further revealed the underlying mechanisms of this pathway (Firouzi et ...
متن کاملA phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury.
Multiple lines of evidence have validated the Rho pathway as important in controlling the neuronal response to growth inhibitory proteins after central nervous system (CNS) injury. A drug called BA-210 (trademarked as Cethrin(®)) blocks activation of Rho and has shown promise in pre-clinical animal studies in being used to treat spinal cord injury (SCI). This is a report of a Phase I/IIa clinic...
متن کاملMethylprednisolone in Acute Spinal Cord Injury
EVIDENCE DEFINITIONS Class I: Prospective randomized controlled trial. Class II: Prospective clinical study or retrospective analysis of reliable data. Includes observational, cohort, prevalence, or case control studies. Class III: Retrospective study. Includes database or registry reviews, large series of case reports, expert opinion. Technology assessment: A technology study which doe...
متن کاملSpinal cord injury: acute care management.
This article has been subjected to double blind peer review The first two articles in this series described the anatomy and physiology of the vertebral column and spinal cord, and examined the aetiology and pathophysiology of spinal cord injuries (Sheerin 2004, 2005). These provide a basis for understanding the presentation and management of spinal cord injuries. It is difficult to be prescript...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Neurology
سال: 2013
ISSN: 1664-2295
DOI: 10.3389/fneur.2013.00005